Bretylium tosylate in prevention of cardiac dysrhythmias after myocardial infarction

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Bretylium tosylate in prevention of cardiac dysrhythmias after myocardial infarction.

The prophylactic value of parenterally administered bretylium tosylate against the onset of dysrhythmias after acute myocardial infarction has been assessed by a controlled trial in 101 male patients. Bretylium significantly reduced the incidence of supraventricular dysrhythmias but was without significant effect on the incidence of ventricular dysrhythmias. The only serious side-effect of the ...

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Prevention of chronic canine ventricular tachyarrhythmias with bretylium tosylate.

The ability of chronic bretylium tosylate treatment to prevent the induction of ventricular tachycardia was assessed in the conscious dog subjected to serial programmed ventricular stimulation on days 3-6 after acute myocardial infarction. In 34 untreated control dogs, programmed ventricular stimulation produced nonsustained ventricular tachycardia in 11 dogs (32%), sustained ventricular tachyc...

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Bretylium tosylate in treatment of refractory ventricular arrhythmias complicating myocardial infarction.

In IO patients with severe myocardial infarction and left ventricular failure, bretylium tosylate was used in the treatment of ventricular arrhythmias which had proved refractory to lignocaine and procainamide; 6 cases had also failed to respond to phenytoin. In 7 patients stable sinus rhythm was achieved and 5 of these survived to leave hospital. For the period during which bretylium was used,...

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Experience with bretylium tosylate by a hospital cardiac arrest team.

The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intravenous propranolol, diphenylhydantoin or procainamide. Following 30 min of su...

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Life threatening ventricular dysrhythmias:

Cardiac arrhythmias following acute myocardial infarction are often fatal. Although commonly used antiarrhythmics are usually effective, some patients develop dysrhythmias that are refractory to these medications. This article discusses the use and contraindications of bretylium tosylate, a relatively new antiarrhythmic drug that has been shown to be effective in reversing dysrhythmias that wer...

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ژورنال

عنوان ژورنال: Heart

سال: 1970

ISSN: 1355-6037

DOI: 10.1136/hrt.32.3.326